Project Description
The project aims to develop a data processing analysis pipeline for retinal imaging ophthalmoscopes with spectral and time-resolved measurement capabilities, to detect signatures of severe diseases from ophthalmic data. This unique ophthalmic system is built around a single-photon avalanche photodiode (SPAD) line sensor array with single-photon time-resolved detection [1]. It produces complex and abundant data requiring the development of new data processing and analysis tools to extract accurate and insightful information about the eye’s function and pathology. Specifically, the project will focus on early detection of Alzheimer’s disease [2], the most common form of dementia.
The project’s main focus will be the development of data processing and analysis tools, including the use of artificial intelligence and on-board FPGA processing. This will require characterization of the instrument, algorithm development, tests on physical models of the eye and/or simulated data, and finally data from measurements on the human eye. The student will be deeply embedded in a friendly, multidisciplinary, efficient, and highly experienced team of scientists and engineers specializing in optics, spectroscopy, software engineering, electronics, signal processing, and ophthalmoscopy. They will be rigorously trained in common scientific research principles and specialize in spectroscopy, ophthalmoscopy, and software development.
The student must clearly show interest and capability in conducting multidisciplinary research, particularly with a bioimaging and medical focus. They need to have experience or with data analysis or signal processing, neural networks and/or FPGA firmware development.
[1] A. T. Erdogan et al. (2019) IEEE J Solid-State Circuits, 54(6), 1705-1719, https://doi.org/10.1109/JSSC.2019.2894355.
[2] S. Jentsch et al. (2015) Acta Ophthalmol, 93, e241-e247, https://doi.org/10.1111/aos.12609.
CDT Essential Criteria
A Masters level degree (MEng, MPhys, MSc) at 2.1 or equivalent
Desire to work collegiately, be involved in outreach, undertake taught and professional skills study
Project Essential Criteria
Experience in data analysis, signal processing, neural networks or FPGA firmware development.
Project Desirable Criteria
Experience in fluorescence measurements.
Experience in optics and imaging systems.
The CDT
The CDT in Applied Photonics provides a supportive, collaborative environment which values inclusivity and is committed to creating and sustaining a positive and supportive environment for all our applicants, students, and staff. For further information, please see our ED&I statement: https://bit.ly/3gXrcwg.
Forming a supportive cohort is an important part of the programme and our students take part in various professional skills workshops, including Responsible Research and Innovation, and attend outreach training.
