Project Description
The successful EngD candidate will join Northern Light Microscopy (NLM) – a dynamic recent spin-out company from the University of Strathclyde who lead in the development of advanced microscopy systems for direct use on life-sciences lab benches – and lead research on developing multi-modal super-resolution microscopy technology with capabilities to sense deep into biological samples.
Microscopy systems are one of the key technology components for life science discoveries, underpinning the old saying of “seeing is believing” and unlocking the visualisation of the structure and dynamics of life’s building blocks.
Specifically, advanced systems with resolution to identify intra-cellular components and single molecule dynamics in high-throughput fashion are key to the next bioscience discoveries. While great steps have been done to reach nanometer resolution levels, key challenges are still to achieve this level of detail in live cells and specimens, and translate this into imaging at depth and in high-throughput fashion to screen for the next generation of drug discoveries and understanding of biological processes. In this EngD project you will work with advanced super-resolution techniques and push the boundaries towards benchtop tools that can image at speed, at depth and resolve the most intricate details.
Specifically you will be working on structured illumination microscopy (SIM) technology and investigate hardware and software approaches that allow reduction of influences from background signals in biological specimens. For this you will develop new combinations of confocal-like imaging approaches and package it with flexible SIM hardware to lead the potential of investigating multiple methods at the same time.
You will work at NLM in their R&D team, collaborating closely with the company’s leadership team under CEO Dr Peter Tinning (NLM) and with Dr Ralf Bauer (University of Strathclyde) in the department of Electronic and Electrical Engineering (EEE). You will gain hands-on training and experience in commercial microscopy systems and advanced research prototypes from laboratory feasibility to real-world validation. You will work collaboratively across academia and industry, with the position offering extensive professional development from both technical and commercial perspectives, as well as leadership training and opportunities to publish and present your work at international conferences next to engaging with real-world users of your technology.
We are a bright, engaging, welcoming and helpful team and we invite applications from individuals who want to make a difference and contribute to the development of high-impact photonics-based solutions.
CDT Essential Criteria
A Masters level degree (MPhys, MSc) at 2.1 or equivalent.
Desire to work collegiately, be involved in outreach, undertake taught and professional skills study.
Project Essential Criteria
A strong interest in optical imaging and engineering for microscopy, with the drive to carry out sustained, original research leading to doctoral-level contributions.
A desire to undertake hands-on activities across a range of topics.
Ability to analyse, process and interpret experimental data.
Excellent written and verbal communication skills, with the ability to present research clearly and collaborate effectively within multidisciplinary teams.
Project Desirable Criteria
Familiarity with scientific programming tools (e.g., ImageJ, Python, C#, etc.) for instrument control, data acquisition, and image processing
An interest in electronics and instrumentation.
Hands-on experience with laboratory optical setups and instrumentation.
The CDT
The CDT in Applied Photonics provides a supportive, collaborative environment which values inclusivity and is committed to creating and sustaining a positive and supportive environment for all our applicants, students, and staff. For further information, please see our ED&I statement: https://bit.ly/3gXrcwg.
Forming a supportive cohort is an important part of the programme and our students take part in various professional skills workshops, including Responsible Research and Innovation, and attend outreach training.